Type 1 inflammatory endotype relates to low compliance, lung fibrosis, and severe complications in COVID-19.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) is an acute respiratory disease; approximately 5% of patients developing severe COVID-19. It is known that cytokine release is associated with disease severity, but the relationship between the different clinical phenotypes and inflammatory endotypes is not well understood.

Objective

This study investigated the association between inflammatory biomarker-based endotypes and severe COVID-19 phenotypes.

Methods

Interleukin (IL) -6, C-reactive protein (CRP), C-X-C motif chemokine (CXCL) 9, IL-18, C-C motif chemokine (CCL) 3, CCL17, IL-10, and vascular endothelial growth factor (VEGF) were measured in 57 COVID-19 patients, and their association with clinical characteristics was examined using a cluster analysis.

Results

SUBMITTER: Hasegawa T 

PROVIDER: S-EPMC8180668 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature