No Sex Differences in Bone Mineral Accretion From 1 to 12 Months of Age Among a Sample of Healthy Term Breastfed Infants From Montreal, Canada

ABSTRACT: Abstract

Objectives

To investigate sex differences in bone mass including whole body (WB) bone mineral content (BMC), lumbar spine (LS) BMC and LS bone mineral density (BMD) during infancy.

Methods

This is a secondary analysis of data from a double-blinded randomized clinical trial (NCT00381914), in which healthy term breastfed infants were randomized to 1 of 4 doses of oral vitamin D supplementation (400−1600 IU/d) at 1 mo of age (+/− 2 wk). Serum 25-hydroxyvitamin D (25(OH)D) using liquid chromatography-tandem mass spectrometry, and BMC and BMD using dual-energy x-ray absorptiometry (Hologic) were measured at 1, 3, 6, 9, and 12 mo of age (+/- 2 wk). No effect of supplementation on BMC (WB and LS) and BMD (LS) was reported in the primary study. Infants (32 males (M), 31

SUBMITTER:  

PROVIDER: S-EPMC8180808 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature