Deletion of Clusterin Protects Cochlear Hair Cells against Hair Cell Aging and Ototoxicity.

ABSTRACT: Hearing loss is a debilitating disease that affects 10% of adults worldwide. Most sensorineural hearing loss is caused by the loss of mechanosensitive hair cells in the cochlea, often due to aging, noise, and ototoxic drugs. The identification of genes that can be targeted to slow aging and reduce the vulnerability of hair cells to insults is critical for the prevention of sensorineural hearing loss. Our previous cell-specific transcriptome analysis of adult cochlear hair cells and supporting cells showed that Clu, encoding a secreted chaperone that is involved in several basic biological events, such as cell death, tumor progression, and neurodegenerative disorders, is expressed in hair cells and supporting cells. We generated Clu-null mice (C57BL/6) to investigate its role

SUBMITTER: Zhao X 

PROVIDER: S-EPMC8181089 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature