Construction and Validation of an Autophagy-Related Prognostic Model for Osteosarcoma Patients.

ABSTRACT: While the prognostic value of autophagy-related genes (ARGs) in OS patients remains scarcely known, increasing evidence is indicating that autophagy is closely associated with the development and progression of osteosarcoma (OS). Therefore, we explored the prognostic value of ARGs in OS patients and illuminate associated mechanisms in this study. When the OS patients in the training/validation cohort were stratified into high- and low-risk groups according to the risk model established using least absolute shrinkage and selection operator (LASSO) regression analysis, we observed that patients in the low-risk group possessed better prognosis (P < 0.0001). Univariate/Multivariate COX regression and subgroup analysis demonstrated that the ARGs-based risk model was an independent surviv

SUBMITTER: Qian H 

PROVIDER: S-EPMC8181090 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature