Further Biochemical Profiling of <i>Hypholoma fasciculare</i> Metabolome Reveals Its Chemogenetic Diversity.

ABSTRACT: Natural products with novel chemistry are urgently needed to battle the continued increase in microbial drug resistance. Mushroom-forming fungi are underutilized as a source of novel antibiotics in the literature due to their challenging culture preparation and genetic intractability. However, modern fungal molecular and synthetic biology tools have renewed interest in exploring mushroom fungi for novel therapeutic agents. The aims of this study were to investigate the secondary metabolites of nine basidiomycetes, screen their biological and chemical properties, and then investigate the genetic pathways associated with their production. Of the nine fungi selected, Hypholoma fasciculare was revealed to be a highly active antagonistic species, with antimicrobial activity against three

SUBMITTER: Al-Salihi SAA 

PROVIDER: S-EPMC8181146 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature