Plasma HSP90AA1 Predicts the Risk of Breast Cancer Onset and Distant Metastasis.

ABSTRACT:

Aim

We aimed to develop and validate a comprehensive nomogram containing pre-treatment plasma HSP90AA1 to predict the risk of breast cancer onset and metastasis.

Methods

We assessed the expression of HSP90s in breast cancer patients using an online database. To verify the results, 677 patients diagnosed with breast cancer and 146 patients with benign breast disease between 2014 and 2019 were selected from our hospital and were divided into cancer risk and metastasis risk cohorts. We focused on HSP90AA1 to elucidate the risks of onset and metastasis in the cohorts.

Results

Expression levels of HSP90AA1, HSP90AA2, HSP90AB1, HSP90B1, and TRAP1 were linked to disease progression. Survival analysis using the GEPIA and OncoLnc databases in

SUBMITTER: Liu H 

PROVIDER: S-EPMC8181396 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature