Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications?

ABSTRACT: Patients with COVID-19 present a wide spectrum of disease severity, from asymptomatic cases in the majority to serious disease leading to critical care and even death. Clinically, four different scenarios occur within the typical disease timeline: first, an incubation and asymptomatic period; second, a stage with mild symptoms due mainly to the virus itself; third, in up to 20% of the patients, a stage with severe symptoms where a hyperinflammatory response with a cytokine storm driven by host immunity induces acute respiratory distress syndrome; and finally, a post-acute sequelae (PASC) phase, which present symptoms that can range from mild or annoying to actually quite incapacitating. Although the most common manifestation is acute respiratory failure of the lungs, other organs are also

SUBMITTER: Castro P 

PROVIDER: S-EPMC8181544 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature