Assessment of rs4588 Allele Impact on 25-OH-D Concentration in Blood of Caucasian Adults

ABSTRACT: Abstract

Objectives

An important point of contention is whether genetic variation has meaningful impact on vitamin D adequacy on top of known modulators like season, fat mass, skin pigmentation and geographic latitude. Answers could come from information generated by numerous published studies. As a first step towards integration of these often diverse data, the impact of the commonly measured single nucleotide variant rs4588 of the GC gene on 25-hydroxy vitamin D (25OHD) concentration in blood of healthy Caucasian adults was assessed with a systematic review and metaanalysis of published findings.

Methods

Selection criteria for inclusion of studies in the analyses were Caucasian healthy adults and listing of average 25OHD concentration in plasma or serum by rs4588 or the

SUBMITTER:  

PROVIDER: S-EPMC8181666 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature