RNA Binding Protein-Based Model for Prognostic Prediction of Colorectal Cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a kind of gastrointestinal tumor with serious high morbidity and mortality. Several reports have implicated the disorder of RNA-binding proteins (RBPs) in plenty of tumors, associating it to tumorigenesis and disease progression. The study is intended to construct novel prognostic biomarkers associated with CRC patients.

Methods

Data of gene expression was acquired from the TCGA database, prognosis-related genes were selected. Besides, we analyzed GO and KEGG pathways. Univariate and multivariate Cox analyses were performed to generate a prognostic-related gene signature, which was evaluated by the Kaplan-Meier (K-M) and the Receiver Operating Characteristic (ROC) curve. The independent prognostic factor was established by survival analy

SUBMITTER: Li T 

PROVIDER: S-EPMC8182183 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature