Hypoxia further exacerbates woody breast myopathy in broilers via alteration of satellite cell fate.

ABSTRACT: Woody breast (WB) condition has created a variety of challenges for the global poultry industry. To date, there are no effective treatments or preventative measures due to its unknown (undefined) etiology. Several potential mechanisms including oxidative stress, fiber-type switching, cellular damage, and altered intracellular calcium levels have been proposed to play a key role in the progression of the WB myopathy. In a previous study, we have shown that WB is associated with hypoxia-like status and dysregulated oxygen homeostasis. As satellite cells (SC) play a pivotal role in muscle fiber repair and remodeling under stress conditions, we undertook the present study to determine satellite cell fate in WB-affected birds when reared in either normoxic or hypoxic conditions. Modern random b

SUBMITTER: Emami NK 

PROVIDER: S-EPMC8182261 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature