Sex differences in off-target binding using tau positron emission tomography.

ABSTRACT:

Purpose

Off-target binding in the skull and meninges is observed in some subjects undergoing tau positron emission tomography (PET) and could potentially differ between men and women. In this study we elucidate sex differences in tau off-target binding using three different tau PET tracers.

Methods

541 cognitively unimpaired amyloid-β negative participants underwent tau PET using [¹⁸F]flortaucipir (n = 165), [¹⁸F]RO948 (n = 189) and [¹⁸F]MK6240 (n = 187). Baseline SUVR-values were compared between females and males at the voxel level and using a region-of-interest (ROI) encompassing the skull/meninges. In addition, we assessed the cross-sectional relationship between baseline skull/meninges SUVR and age and assessed change in skull/meningeal

SUBMITTER: Smith R 

PROVIDER: S-EPMC8182304 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature