Serum exosomal microRNA-146a as a novel diagnostic biomarker for acute coronary syndrome.

ABSTRACT:

Background

Circulating microRNAs (miRNAs) have emerged as potential biomarkers for cardiovascular diseases. However, few studies have focused on the role of exosomal miRNAs in acute coronary syndrome (ACS). The purpose of this study was to explore weather serum exosomal microRNA-146a (exo-miR-146a) could be used as a novel diagnostic biomarker for ACS and to investigate its relationship with inflammatory response.

Methods

A total of 63 ACS patients and 25 patients with normal coronary arteries (Control) were enrolled respectively. The serum exosomes were isolated and then identified by transmission electron microscopy (TEM), western blot, and nanoparticle tracking analysis (NTA). The expression levels of exo-miR-146a in serum were detected by real-time quantitative polymeras

SUBMITTER: Li LJ 

PROVIDER: S-EPMC8182505 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature