Outcomes related to anticoagulation management for mechanical valve replacements.

ABSTRACT:

Background

This study evaluates anticoagulation management and its impact on longitudinal clinical outcomes in patients undergoing mechanical valve replacement.

Methods

Patients undergoing mechanical mitral valve replacement (MVR) or aortic valve replacement (AVR) from 2010-2018 at a single center were included. Patients were stratified into therapeutic and non-therapeutic anticoagulation groups based on the median percentage of international normalized ratio (INR) values within the reference range (2.0-3.0 for AVR, 2.5-3.5 for MVR) during the first post-operative year. Using Cox regression analysis, comorbidity-adjusted survival and freedom from adverse events were compared.

Results

Six hundred and fifty-one patients underwent mechanical valve replacement (166 MVR, 4

SUBMITTER: Huckaby LV 

PROVIDER: S-EPMC8182532 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature