Earlier extracranial progression and shorter survival in ALK-rearranged lung cancer with positive liquid rebiopsies.

ABSTRACT:

Background

Liquid rebiopsies can detect resistance mutations to guide therapy of anaplastic lymphoma kinase-rearranged (ALK⁺) non-small-cell lung cancer (NSCLC) failing tyrosine kinase inhibitors (TKI). Here, we analyze how their results relate to the anatomical pattern of disease progression and patient outcome.

Methods

Clinical, molecular, and radiologic characteristics of consecutive TKI-treated ALK⁺ NSCLC patients were analyzed using prospectively collected plasma samples and the 17-gene targeted AVENIO kit, which covers oncogenic drivers and all TP53 exons.

Results

In 56 patients, 139 instances of radiologic changes were analyzed, of which 133 corresponded to disease progression. Circulating tumor DNA (ctDNA) alterations were identifi

SUBMITTER: Christopoulos P 

PROVIDER: S-EPMC8182700 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature