M⁵C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in lung adenocarcinoma.

ABSTRACT:

Background

In recent years, immunotherapy has made great progress, and the regulatory role of epigenetics has been verified. However, the role of 5-methylcytosine (m⁵C) in the tumor microenvironment (TME) and immunotherapy response remains unclear.

Methods

Based on 11 m⁵C regulators, we evaluated the m⁵C modification patterns of 572 lung adenocarcinoma (LUAD) patients. The m⁵C score was constructed by principal component analysis (PCA) algorithms in order to quantify the m⁵C modification pattern of individual LUAD patients.

Results

Two m⁵C methylation modification patterns were identified according to 11 m⁵C regulators. The two patterns had a remarkably distinct TME immune cell infiltration c

SUBMITTER: Chen H 

PROVIDER: S-EPMC8182725 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature