A Randomized Case Series Approach to Testing Efficacy of Interventions for Minimally Verbal Autistic Children.

ABSTRACT:

Background

Randomized Controlled Trials (RCTs) are the gold standard for assessing whether an intervention is effective; however, they require large sample sizes in order to detect small effects. For rare or complex populations, we advocate a case series approach as a more realistic and useful first step for intervention evaluation. We consider the importance of randomization to such designs, and advocate for the use of Randomization Tests and Between Case Effect Sizes to provide a robust and statistically powerful evaluation of outcomes. In this tutorial, we describe the method, procedures, and analysis code necessary to conduct robust single case series, using an empirical example with minimally verbal autistic children.

Method

We applied a pre-registered (https://osf.io/9

SUBMITTER: Saul J 

PROVIDER: S-EPMC8182798 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature