Destination shapes antibiotic resistance gene acquisitions, abundance increases, and diversity changes in Dutch travelers.

ABSTRACT:

Background

Antimicrobial-resistant bacteria and their antimicrobial resistance (AMR) genes can spread by hitchhiking in human guts. International travel can exacerbate this public health threat when travelers acquire AMR genes endemic to their destinations and bring them back to their home countries. Prior studies have demonstrated travel-related acquisition of specific opportunistic pathogens and AMR genes, but the extent and magnitude of travel's effects on the gut resistome remain largely unknown.

Methods

Using whole metagenomic shotgun sequencing, functional metagenomics, and Dirichlet multinomial mixture models, we investigated the abundance, diversity, function, resistome architecture, and context of AMR genes in the fecal microbiomes of 190 Dutch individuals, before a

SUBMITTER: D'Souza AW 

PROVIDER: S-EPMC8182900 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature