Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens.

ABSTRACT:

Background

Microbiome interactions are important determinants for ecosystem functioning, stability, and health. In previous studies, it was often observed that bacteria suppress potentially pathogenic fungal species that are part of the same plant microbiota; however, the underlying microbe-microbe interplay remains mostly elusive. Here, we explored antagonistic interactions of the fungus Fusarium graminearum and bacterium Streptomyces hygroscopicus at the molecular level. Both are ubiquitous members of the healthy wheat microbiota; under dysbiosis, the fungus causes devastating diseases.

Results

In co-cultures, we found that Streptomyces alters the fungal acetylome leading to substantial induction of fungal autophagy. The bacterium secrets rapamycin to inactivate the target

SUBMITTER: Wang J 

PROVIDER: S-EPMC8182927 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature