Circular RNA expression profile in transgenic diabetic mouse kidneys.

ABSTRACT:

Background

Diabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis of diabetic nephropathy remain unclear. Several studies have indicated that circular RNAs (circRNAs) play crucial regulatory roles in numerous human diseases and normal physiology; however, to date, no study has focused on the comprehensive expression profile of circRNAs in the kidneys of diabetic mice. Therefore, we aimed to identify differentially expressed circRNAs in diabetic mouse kidneys to explore the possible roles of dysregulated circRNAs in diabetic nephropathy development.

Results

Diabetic BKS-Lepr^em2Cd479/Nju (BKS-DB/Nju) mice and their nondiabetic wild-type littermates of C57BL/KsJ wild-type (WT) mice were used as experim

SUBMITTER: Xiong X 

PROVIDER: S-EPMC8182942 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature