Identification of COVID-19 B-cell epitopes with phage-displayed peptide library.

ABSTRACT:

Background

Coronavirus disease 19 (COVID-19) first appeared in the city of Wuhan, in the Hubei province of China. Since its emergence, the COVID-19-causing virus, SARS-CoV-2, has been rapidly transmitted around the globe, overwhelming the medical care systems in many countries and leading to more than 3.3 million deaths. Identification of immunological epitopes on the virus would be highly useful for the development of diagnostic tools and vaccines that will be critical to limiting further spread of COVID-19.

Methods

To find disease-specific B-cell epitopes that correspond to or mimic natural epitopes, we used phage display technology to determine the targets of specific antibodies present in the sera of immune-responsive COVID-19 patients. Enzyme-linked immunosorbent assays

SUBMITTER: Guo JY 

PROVIDER: S-EPMC8182997 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature