A seven-gene prognostic signature predicts overall survival of patients with lung adenocarcinoma (LUAD).

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is one of the most common types in the world with a high mortality rate. Despite advances in treatment strategies, the overall survival (OS) remains short. Our study aims to establish a reliable prognostic signature closely related to the survival of LUAD patients that can better predict prognosis and possibly help with individual monitoring of LUAD patients.

Methods

Raw RNA-sequencing data were obtained from Fudan University and used as a training group. Differentially expressed genes (DEGs) for the training group were screened. The univariate, least absolute shrinkage and selection operator (LASSO), and multivariate cox regression analysis were conducted to identify the candidate prognostic genes and construct the risk score model. Kap

SUBMITTER: Al-Dherasi A 

PROVIDER: S-EPMC8183047 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature