IL10RB as a key regulator of COVID-19 host susceptibility and severity.

ABSTRACT:

Background

Recent efforts have identified genetic loci that are associated with coronavirus disease 2019 (COVID-19) infection rates and disease outcome severity. Translating these genetic findings into druggable genes and readily available compounds that reduce COVID-19 host susceptibility is a critical next step.

Methods

We integrate COVID-19 genetic susceptibility variants, multi-tissue genetically regulated gene expression (GReX) and perturbargen signatures to identify candidate genes and compounds that reverse the predicted gene expression dysregulation associated with COVID-19 susceptibility. The top candidate gene is validated by testing both its GReX and observed blood transcriptome association with COVID-19 severity, as well as by in vitro perturbation to quan

SUBMITTER: Voloudakis G 

PROVIDER: S-EPMC8183086 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature