Transdermal nicotine in non-smokers: A systematic review to design COVID-19 clinical trials.

ABSTRACT: Recent data show an interaction between COVID-19 and nicotine and indicate the need for an assessment of transdermal nicotine use in non-smokers. Assessments have been conducted into the short-term cognitive effects of nicotine and into diseases such as Parkinson's, Tourette syndrome, ADHD or ulcerative colitis.

Methods

Analyses of nicotine administration protocols and safety were conducted after reviewing Medline and Science Direct databases performing a search using the words [transdermal nicotine] AND [non-smoker] AND selected diseases.

Results

Among 298 articles identified, there were 35 reviewed publications reporting on 33 studies of non-smokers receiving transdermal nicotine for >48hours. In the 16 randomized trials, 7 crossover, 1 case/control and 9 open studies patie

SUBMITTER: Dautzenberg B 

PROVIDER: S-EPMC8183099 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature