Patient Determinants for Histologic Diagnosis of NAFLD in the Real World: A TARGET-NASH Study.

ABSTRACT: Much of the current data on nonalcoholic fatty liver disease (NAFLD) are derived from biopsy-based studies that may introduce ascertainment and selection bias. Selection of patients for liver biopsy has implications for clinical practice and the reported epidemiology of NAFLD. The aim of this study was to determine patient factors predictive of histologic versus empiric clinical diagnosis of NAFLD in real-world practice. Adults from TARGET-NASH were included in this study. Descriptive statistics are provided for the cohort and compare the characteristics of histologic NAFLD versus patients with clinically diagnosed NAFLD, followed by logistic regression and machine-learning models to describe predictors of liver biopsy. The records of 3,474 subjects were analyzed; median age was 59 years,

SUBMITTER: Barritt AS 

PROVIDER: S-EPMC8183178 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature