Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells.

ABSTRACT: The vast majority (>90%) of glioblastoma (GBM) patients belong to the isocitrate dehydrogenase 1 wild type (IDH1^WT) group which exhibits a poor prognosis with a median survival of less than 15 months. This study demonstrated numerous immunosuppressive genes as well as β-catenin gene, pivotal for Wnt/β-catenin signaling, were upregulated in 206 IDH1^WT glioma patients using the Chinese Glioma Genome Atlas (CGGA) database. The increase in microglia with an immunosuppressive phenotype and the overexpression of β-catenin protein were further verified in IDH1^WT GBM patients and IDH1^WT GL261 glioma allografts. Subsequently, we found that IDH1^WT GL261 cell-derived conditioned medium activated Wnt/β-catenin signaling in primary microglia and tr

SUBMITTER: Fan D 

PROVIDER: S-EPMC8183516 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature