Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients.

ABSTRACT: CD103-positive tissue resident memory-like CD8⁺ T cells (CD8CD103 TRM) are associated with improved prognosis across malignancies, including high-grade serous ovarian cancer (HGSOC). However, whether quantification of CD8, CD103 or both is required to improve existing survival prediction and whether all HGSOC patients or only specific subgroups of patients benefit from infiltration, remains unclear. To address this question, we applied image-based quantification of CD8 and CD103 multiplex immunohistochemistry in the intratumoral and stromal compartments of 268 advanced-stage HGSOC patients from two independent clinical institutions. Infiltration of CD8CD103 immune cell subsets was independent of clinicopathological factors. Our results suggest CD8CD103 TRM quantification as a su

SUBMITTER: Paijens ST 

PROVIDER: S-EPMC8183551 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature