Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery.

ABSTRACT: The crisis of antibiotic resistance necessitates creative and innovative approaches, from chemical identification and analysis to the assessment of bioactivity. Plant natural products (NPs) represent a promising source of antibacterial lead compounds that could help fill the drug discovery pipeline in response to the growing antibiotic resistance crisis. The major strength of plant NPs lies in their rich and unique chemodiversity, their worldwide distribution and ease of access, their various antibacterial modes of action, and the proven clinical effectiveness of plant extracts from which they are isolated. While many studies have tried to summarize NPs with antibacterial activities, a comprehensive review with rigorous selection criteria has never been performed. In this work, the literat

SUBMITTER: Porras G 

PROVIDER: S-EPMC8183567 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature