Fewer gastrointestinal bleeds with ticagrelor and prasugrel compared with clopidogrel in patients with acute coronary syndrome following percutaneous coronary intervention.

ABSTRACT:

Background

Gastrointestinal bleeding (GIB) frequently occurs following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) with the prescription of P2Y₁₂ inhibiting antiplatelet agents. Compared with clopidogrel, the newer P2Y₁₂ inhibitors lower major adverse cardiac events with similar or possibly higher major bleeding events. The comparative GIB rates of these medications remain poorly understood.

Aim

To compare GIB rates associated with clopidogrel, prasugrel and ticagrelor using national medical and pharmacy claims data from privately insured and Medicare Advantage enrollees .

Methods

Propensity score and inverse probability treatment weighting were used to balance baseline characteristics among treatment groups. The 1-

SUBMITTER: Abraham NS 

PROVIDER: S-EPMC8183594 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature