Shape memory polymer (SMP) scaffolds with improved self-fitting properties.

ABSTRACT: "Self-fitting" shape memory polymer (SMP) scaffolds prepared as semi-interpenetrating networks (semi-IPNs) with crosslinked linear-poly(ε-caprolactone)-diacrylate (PCL-DA, M_n∼10 kg mol^-1) and linear-poly(l-lactic acid) (PLLA, M_n∼15 kg mol^-1) [75/25 wt%] exhibited robust mechanical properties and accelerated degradation rates versus a PCL-DA scaffold control. However, their potential to treat irregular craniomaxillofacial (CMF) bone defects is limited by their relatively high fitting temperature (T_fit∼55 °C; related to the T_m of PCL) required for shape recovery (i.e. expansion) and subsequent shape fixation during press fitting of the scaffold, which can be harmful to surrounding tissue. Additionally, the viscosity of the sol

SUBMITTER: Pfau MR 

PROVIDER: S-EPMC8183596 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature