A serological assay to detect SARS-CoV-2 seroconversion in humans.
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ABSTRACT:
SUBMITTER: Amanat F
PROVIDER: S-EPMC8183627 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
A serological assay to detect SARS-CoV-2 seroconversion in humans.
Amanat Fatima F Stadlbauer Daniel D Strohmeier Shirin S Nguyen Thi H O THO Chromikova Veronika V McMahon Meagan M Jiang Kaijun K Arunkumar Guha Asthagiri GA Jurczyszak Denise D Polanco Jose J Bermudez-Gonzalez Maria M Kleiner Giulio G Aydillo Teresa T Miorin Lisa L Fierer Daniel S DS Lugo Luz Amarilis LA Kojic Erna Milunka EM Stoever Jonathan J Liu Sean T H STH Cunningham-Rundles Charlotte C Felgner Philip L PL Moran Thomas T García-Sastre Adolfo A Caplivski Daniel D Cheng Allen C AC Kedzierska Katherine K Vapalahti Olli O Hepojoki Jussi M JM Simon Viviana V Krammer Florian F
Nature medicine 20200512 7
Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to scaling. Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate corre ...[more]
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