TP53 missense mutation is associated with increased tumor-infiltrating T cells in primary prostate cancer.

ABSTRACT: The makeup of the tumor immune microenvironment may be associated with tumor somatic genomic alterations and plays a key role in tumor progression and response to immunotherapy. We examined the association of tumor-infiltrating T-cell density with TP53 status in surgically treated primary prostate cancer using 3 independent tissue microarray sets, including one set of tumors from grade-matched patients of European American or African American ancestry (n = 391), a retrospective case-cohort of intermediate- and high-risk patients enriched for adverse outcomes (n = 267), and a set of tumors with primary Gleason pattern 5 (n = 77). The presence of TP53 missense mutation, indicated by p53 nuclear accumulation using a genetically validated assay, was significantly associated with increased CD3+

SUBMITTER: Kaur HB 

PROVIDER: S-EPMC8183670 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature