Diagnostic value of loop-mediated isothermal amplification assay for hand, foot, and mouth disease.

ABSTRACT:

Background

Nowadays, hand, foot, and mouth disease (HFMD) has a significant negative impact on children's health, especially in the Asia-Pacific region. Loop-mediated isothermal amplification assay (LAMP) is a highly efficient and convenient novel tool. However, its diagnostic accuracy for HFMD is still not clear. Therefore, we conducted a meta-analysis in order to evaluate the potential of LAMP assay for the diagnosis of HFMD, in which the reference standard was polymerase chain reaction (PCR).

Methods

A protocol was predetermined (CRD42020212882) in PROSPERO. We retrieved seven databases including PubMed for relevant studies published before October 2020. Articles were included if they compared the diagnostic efficiency of LAMP with PCR for HFMD through detecting clinical

SUBMITTER: Chen YZ 

PROVIDER: S-EPMC8183915 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature