Expression profiles of circular RNAs in colon biopsies from Crohn's disease patients by microarray analysis.

ABSTRACT:

Background

Circular RNAs (circRNAs) are involved in various diseases and serve as biomarkers. The present study aimed to investigate unique expression profiles of circRNAs in colon tissues of Crohn's disease (CD) and search novel biomarkers for the diagnosis.

Methods

Differentially expressed (DE) circRNAs in biopsies from four CD patients, four ulcerative colitis (UC) patients, and four healthy controls (HC) were screened by microarray. Hsa_circ_0062142 and hsa_circ_0001666 were verified in another expanded validation cohort. Bioinformatics analysis was applied to predict the function of two DE circRNAs. Receiver operating characteristic (ROC) curves were constructed to evaluate the diagnostic value of CD.

Results

The top 10 upregulated circRNAs in CD compared with HC

SUBMITTER: Hu YA 

PROVIDER: S-EPMC8183921 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature