A ten N6-methyladenosine-related long non-coding RNAs signature predicts prognosis of triple-negative breast cancer.

ABSTRACT:

Background

Patients with triple-negative breast cancer (TNBC) face a major challenge of the poor prognosis, and N6-methyladenosine-(m6A) mediated regulation in cancer has been proposed. Therefore, this study aimed to explore the prognostic roles of m6A-related long non-coding RNAs (LncRNAs) in TNBC.

Methods

Clinical information and expression data of TNBC samples were collected from TCGA and GEO databases. Pearson correlation, univariate, and multivariate Cox regression analysis were employed to identify independent prognostic m6A-related LncRNAs to construct the prognostic score (PS) risk model. Receiver operating characteristic (ROC) curve was used to evaluate the performance of PS risk model. A competing endogenous RNA (ceRNA) network was established for the functional an

SUBMITTER: Wu J 

PROVIDER: S-EPMC8183938 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature