Naive CD8⁺ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity.

ABSTRACT:

Objective

Cardiovascular disease (CVD) remains a significant global health concern with a high degree of mortality. While CD4⁺ T cells have been extensively studied in CVD, the importance of CD8⁺ T cells in this disease, despite their abundance and increased activation in human atherosclerotic plaques, remains largely unknown. Thus, the objective of this study was to compare peripheral T-cell signatures between humans with a high (severe) risk of CVD (including myocardial infarction or stroke) and those with a low risk of CVD. Approach and Results: Using mass cytometry, we uncovered a naive CD8⁺ T (T_N) cell population expressing CD95 (termed CD95⁺CD8⁺ stem cell memory T [CD8 T_SCM] cells) that was enriched

SUBMITTER: Padgett LE 

PROVIDER: S-EPMC8184121 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature