Spatial Association between Gastric Cancer Mortality and Goiter in Sardinia.

ABSTRACT:

Background

Gastric cancer (GC) is the third leading cause of cancer mortality worldwide. The incidence of GC varies between countries according to exposure to different risk factors. Hypothyroidism has been suggested as a potential GC risk factor. In Sardinia, Italy, the prevalence of endemic goiter is high and GC mortality is unevenly distributed. This ecological study aimed to investigate GC mortality and its relationship with hypothyroidism, adjusting for potential confounders.

Methods

The spatial association between GC mortality and goiter (a proxy of hypothyroidism), diet, stature and pastoralism (a proxy of Helicobacter pylori infection), available at the aggregated level, was modelled in the island's 377 municipalities, separately by sex, using geographically weighted

SUBMITTER: Pes GM 

PROVIDER: S-EPMC8184186 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature