Association between Genetic Polymorphisms of miR-1307, miR- 1269, miR-3117 and Breast Cancer Risk in a Sample of South East Iranian Women.

ABSTRACT:

Introduction

MicroRNAs (miRNAs) play an essential role in the susceptibility and development of cancer cells.

Objective

Examining the dependency of breast cancer risk with genetic polymorphisms of miR-1307, miR-1269, and miR-3117 in a sample of Iranian women (southeast region).

Methods

The case-control study consisted of 520 individuals (260 diagnosed BC patients, 260 healthy individuals). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping of miR-1307 rs7911488, miR-1269 rs73239138, and miR-3117 (rs4655646 and rs7512692) polymorphisms.

Results and conclusion

This study provided evidence that miR-1307 rs7911488 polymorphism significantly reduced the risk of BC in heterozygous AG genotype, as well as d

SUBMITTER: Sarabandi S 

PROVIDER: S-EPMC8184203 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature