Stimulus-dependent relationships between behavioral choice and sensory neural responses.

ABSTRACT: Understanding perceptual decision-making requires linking sensory neural responses to behavioral choices. In two-choice tasks, activity-choice covariations are commonly quantified with a single measure of choice probability (CP), without characterizing their changes across stimulus levels. We provide theoretical conditions for stimulus dependencies of activity-choice covariations. Assuming a general decision-threshold model, which comprises both feedforward and feedback processing and allows for a stimulus-modulated neural population covariance, we analytically predict a very general and previously unreported stimulus dependence of CPs. We develop new tools, including refined analyses of CPs and generalized linear models with stimulus-choice interactions, which accurately assess the stimul

SUBMITTER: Chicharro D 

PROVIDER: S-EPMC8184215 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature