Estimation of the Motor Threshold for Near-Rectangular Stimuli Using the Hodgkin-Huxley Model.

ABSTRACT: The motor threshold measurement is a standard in preintervention probing in TMS experiments. We aim to predict the motor threshold for near-rectangular stimuli to efficiently determine the motor threshold size before any experiments take place. Estimating the behavior of large-scale networks requires dynamically accurate and efficient modeling. We utilized a Hodgkin-Huxley (HH) type model to evaluate motor threshold values and computationally validated its function with known true threshold data from 50 participants trials from state-of-the-art published datasets. For monophasic, bidirectional, and unidirectional rectangular stimuli in posterior-anterior or anterior-posterior directions as generated by the cTMS device, computational modeling of the HH model captured the experimentally meas

SUBMITTER: Memarian Sorkhabi M 

PROVIDER: S-EPMC8184325 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature