Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery.

ABSTRACT: The esophagogastric anastomosis is most commonly performed to restore digestive tract continuity after esophagectomy for cancer. Despite a long history of clinical research and development of high-tech staplers, this procedure is still feared by most surgeons and associated with a 10% leakage rate. Among specific factors that may contribute to failure of the esophageal anastomosis are the absence of serosa layer, longitudinal orientation of muscle fibers, and ischemia of the gastric conduit. It has recently been suggested that the gut microbiome may influence the healing process of the anastomosis through the presence of collagenolytic bacterial strains, indicating that suture breakdown is not only a matter of collagen biosynthesis. The esophagogastric anastomosis can be performed either i

SUBMITTER: Bonavina L 

PROVIDER: S-EPMC8184442 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature