A novel, minimally invasive technique to establish the animal model of spinal cord injury.

ABSTRACT:

Background

Spinal cord injury (SCI) is a traumatic disease that is associated with high morbidity, disability, and mortality worldwide. The animal spinal cord contusion model is similar to clinical SCI; therefore, this model is often used to study the pathophysiological changes and treatment strategies for humans after SCI. The present study aimed to introduce a novel, minimally invasive technique to establish an SCI model, and to evaluate its advantages compared with conventional methods.

Methods

Incision length, blood loss, length of time, and model success rate during the operation were recorded. Postoperative hematuria, incision hematoma, scoliosis [detected by micro computed tomography (Micro-CT)] and mortality were analyzed to evaluate surgical complications. The visua

SUBMITTER: Duan H 

PROVIDER: S-EPMC8184457 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature