In vivo calcium imaging reveals disordered interictal network dynamics in epileptic stxbp1b zebrafish.

ABSTRACT: STXBP1 mutations are associated with encephalopathy, developmental delay, intellectual disability, and epilepsy. While neural networks are known to operate at a critical state in the healthy brain, network behavior during pathological epileptic states remains unclear. Examining activity during periods between well-characterized ictal-like events (i.e., interictal period) could provide a valuable step toward understanding epileptic networks. To study these networks in the context of STXBP1 mutations, we combine a larval zebrafish model with in vivo fast confocal calcium imaging and extracellular local field potential recordings. Stxbp1b mutants display transient periods of elevated activity among local clusters of interacting neurons. These network "cascade" even

SUBMITTER: Liu J 

PROVIDER: S-EPMC8184515 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature