Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study.

ABSTRACT:

Purpose

Due to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age, and cognitive function in the general population.

Methods

Two surveys of the population-based Study of Health in Pomerania (SHIP) conducted in Northeast Germany were used. In total, 2653 participants underwent brain magnetic resonance imaging (MRI) and were included in the primary analysis. They were divided into two groups according to their PPI intake and compared with regard to their brain volumes (gray matter, white matter, total brain, and hippocampus) and estimated brain age. Multiple regression was used to adjust for confounding factors. Cognitive functi

SUBMITTER: Ahn N 

PROVIDER: S-EPMC8184524 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature