Liver Injury Associated with Metamizole Exposure: Features of an Underestimated Adverse Event.

ABSTRACT:

Introduction and objective

The potential of metamizole to cause drug-induced liver injury (DILI) has received increasing attention. We investigated the distinguishing features of a case series comprising 32 patients with suspected metamizole-induced DILI.

Methods

For the current analysis, 32 of 238 patients with DILI included in our prospective study on drugs potentially causing DILI were included. Diagnosis of DILI was based on expert opinion and RUCAM (Roussel Uclaf Causality Assessment Method) score and supported by an in vitro test using monocyte-derived hepatocyte-like cells.

Results

Suspected metamizole-DILI was characterised by a female predominance, hepatocellular pattern of injury, high proportion of antinuclear antibody positivity, and predominance of eosino

SUBMITTER: Weber S 

PROVIDER: S-EPMC8184550 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature