Aspirin in people with dementia, long-term benefits, and harms: a systematic review.

ABSTRACT:

Purpose

People with dementia may have indications for aspirin prescription and clinicians are asked to balance the potential risks against benefits. This review examines the evidence for the risk and benefit of long-term aspirin use in people with dementia aged over 65 years, including randomised controlled trials and observational studies.

Methods

We searched three databases for research published between 2007 and 2020. Each eligible article was assessed for risk of bias, and confidence in findings was rated using Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Results

Four papers met inclusion criteria: one randomised controlled trial, two cohort studies, and one with pooled data. All looked only at dementia of Alzheimer's type, and none a

SUBMITTER: Davis KAS 

PROVIDER: S-EPMC8184554 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature