Mast cell-derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the T_H1 cell response to cutaneous antigen exposure.

ABSTRACT:

Background

Atopic dermatitis (AD) is characterized by a skin barrier defect aggravated by mechanical injury inflicted by scratching, a T_H2 cell-dominated immune response, and susceptibility to viral skin infections that are normally restrained by a T_H1 cell response. The signals leading to a T_H2 cell-dominated immune response in AD are not completely understood.

Objective

Our aim was to determine the role of IL-13 in initiation of the T_H cell response to cutaneously encountered antigens.

Methods

Wild-type, Il13^-/-, Il1rl1^-/-, and Il4ra^-/- mice, as well as mice with selective deficiency of IL-13 in mast cells (MCs) were studied; in addition, dendritic cells (DCs) purified from the draining lym

SUBMITTER: Leyva-Castillo JM 

PROVIDER: S-EPMC8184568 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature