Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa.

ABSTRACT:

Background

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, painful, and burdensome inflammatory disease manifesting in nodules and abscesses, with progression to chronically draining tunnels in later-stage disease.

Objective

We sought to determine whether HS tunnels are immunologically active participants in disease activity.

Methods

Skin biopsy specimens were obtained by using ultrasound guidance in untreated patients with HS and those enrolled in an open-label study of brodalumab (ClinicalTrials.gov identifier NCT03960268) for patients with moderate-to-severe HS.

Results

Immunohistochemistry of HS biopsy specimens demonstrated that the epithelialized HS tunnels recapitulate the psoriasiform epidermal hyperplasia morphology of the over

SUBMITTER: Navrazhina K 

PROVIDER: S-EPMC8184580 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature