COPD-associated miR-145-5p is downregulated in early-decline FEV₁ trajectories in childhood asthma.

ABSTRACT:

Background

Many microRNAs (miRNAs) have been associated with asthma and chronic obstructive pulmonary disease (COPD). Longitudinal lung function growth trajectories of children with asthma-normal growth, reduced growth (RG), early decline (ED), and RG with an ED (RGED)-have been observed, with RG and RGED associated with adverse outcomes, including COPD.

Objective

Our aim was to determine whether circulating miRNAs from an early age in children with asthma would be prognostic of reduced lung function growth patterns over the next 16 years.

Methods

We performed small RNA sequencing on sera from 492 children aged 5 to 12 years with mild-to-moderate asthma from the CAMP clinical trial, who were subsequently followed for 12 to 16 years. miRNAs were assessed for differenti

SUBMITTER: Tiwari A 

PROVIDER: S-EPMC8184594 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature