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A structural enriched functional network: An application to predict brain cognitive performance.

ABSTRACT: The structure-function coupling in brain networks has emerged as an important research topic in modern neuroscience. The structural network could provide the backbone of the functional network. The integration of the functional network with structural information can help us better understand functional communication in the brain. This paper proposed a method to accurately estimate the brain functional network enriched by the structural network from diffusion magnetic resonance imaging. First, we adopted a simplex regression model with graph-constrained Elastic Net to construct the functional networks enriched by the structural network. Then, we compared the constructed network characteristics of this approach with several state-of-the-art competing functional network models. Furthermore, we evaluated whether the structural enriched functional network model improves the performance for predicting the cognitive-behavioral outcomes. The experiments have been performed on 218 participants from the Human Connectome Project database. The results demonstrated that our network model improves network consistency and its predictive performance compared with several state-of-the-art competing functional network models.

SUBMITTER: Kim M

PROVIDER: S-EPMC8184595 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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A structural enriched functional network: An application to predict brain cognitive performance.

Kim Mansu M Bao Jingxuan J Liu Kefei K Park Bo-Yong BY Park Hyunjin H Baik Jae Young JY Shen Li L

Medical image analysis 20210304

The structure-function coupling in brain networks has emerged as an important research topic in modern neuroscience. The structural network could provide the backbone of the functional network. The integration of the functional network with structural information can help us better understand functional communication in the brain. This paper proposed a method to accurately estimate the brain functional network enriched by the structural network from diffusion magnetic resonance imaging. First, w ...[more]

PMID: 33848962

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Project description:ObjectiveTraumatic brain injury results in diffuse axonal injury and the ensuing maladaptive alterations in network function are associated with incomplete recovery and persistent disability. Despite the importance of axonal injury as an endophenotype in TBI, there is no biomarker that can measure the aggregate and region-specific burden of axonal injury. Normative modeling is an emerging quantitative case-control technique that can capture region-specific and aggregate deviations in brain networks at the individual patient level. Our objective was to apply normative modeling in TBI to study deviations in brain networks after primarily complicated mild TBI and study its relationship with other validated measures of injury severity, burden of post-TBI symptoms, and functional impairment.MethodWe analyzed 70 T1-weighted and diffusion-weighted MRIs longitudinally collected from 35 individuals with primarily complicated mild TBI during the subacute and chronic post-injury periods. Each individual underwent longitudinal blood sampling to characterize blood protein biomarkers of axonal and glial injury and assessment of post-injury recovery in the subacute and chronic periods. By comparing the MRI data of individual TBI participants with 35 uninjured controls, we estimated the longitudinal change in structural brain network deviations. We compared network deviation with independent measures of acute intracranial injury estimated from head CT and blood protein biomarkers. Using elastic net regression models, we identified brain regions in which deviations present in the subacute period predict chronic post-TBI symptoms and functional status.ResultsPost-injury structural network deviation was significantly higher than controls in both subacute and chronic periods, associated with an acute CT lesion and subacute blood levels of glial fibrillary acid protein (r = 0.5, p = 0.008) and neurofilament light (r = 0.41, p = 0.02). Longitudinal change in network deviation associated with change in functional outcome status (r = -0.51, p = 0.003) and post-concussive symptoms (BSI: r = 0.46, p = 0.03; RPQ: r = 0.46, p = 0.02). The brain regions where the node deviation index measured in the subacute period predicted chronic TBI symptoms and functional status corresponded to areas known to be susceptible to neurotrauma.ConclusionNormative modeling can capture structural network deviations, which may be useful in estimating the aggregate and region-specific burden of network changes induced by TAI. If validated in larger studies, structural network deviation scores could be useful for enrichment of clinical trials of targeted TAI-directed therapies.

Project description:BackgroundThe human brain structure undergoes considerable changes throughout life. Cognitive function can be affected either negatively or positively. It is challenging to segregate normal brain aging from the accelerated one.ObjectiveTo work out a descriptive model of brain structural and functional changes in normal aging.Materials and methodsBy using voxel-based morphometry and lesion segmentation along with linear statistics and machine learning (ML), we analyzed the structural changes in the major brain compartments and modeled the dynamics of neurofunctional performance throughout life. We studied sex differences in lifelong dynamics of brain volumetric data with Mann-Whitney U-test. We tested the hypothesis that performance in some cognitive domains might decline as a linear function of age while other domains might have a non-linear dependence on it. We compared the volumetric changes in the major brain compartments with the dynamics of psychophysiological performance in 4 age groups. Then, we tested linear models of structural and functional decline for significant differences between the slopes in age groups with the T-test.ResultsWhite matter hyperintensities (WMH) are not the major structural determinant of the brain normal aging. They should be viewed as signs of a disease. There is a sex difference in the speed and/or in the onset of the gray matter atrophy. It either starts earlier or goes faster in males. Marked sex difference in the proportion of total cerebrospinal fluid (CSF) and intraventricular CSF (iCSF) justifies that elderly men are more prone to age-related brain atrophy than women of the same age.ConclusionThe article gives an overview and description of the conceptual structural changes in the brain compartments. The obtained data justify distinct patterns of age-related changes in the cognitive functions. Cross-life slowing of decision-making may follow the linear tendency of enlargement of the interhemispheric fissure because the center of task switching and inhibitory control is allocated within the medial wall of the frontal cortex, and its atrophy accounts for the expansion of the fissure. Free online tool at https://med-predict.com illustrates the tests and study results.

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A structural enriched functional network: An application to predict brain cognitive performance.

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A structural enriched functional network: An application to predict brain cognitive performance.

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