Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: A graded-O₂ study in piglets.

ABSTRACT:

Purpose

To validate two neonatal cerebral venous oxygenation (Y_v ) MRI techniques, T₂ relaxation under phase contrast (TRUPC) and accelerated TRUPC (aTRUPC) MRI, with oxygenation measured with direct blood sampling.

Methods

In vivo experiments were performed on seven healthy newborn piglets. For each piglet, a catheter was placed in the superior sagittal sinus to obtain venous blood samples for blood gas oximetry measurement as a gold standard. During the MRI experiment, three to five venous oxygenation levels were achieved in each piglet by varying inhaled O₂ content and breathing rate. Under each condition, Y_v values of the superior sagittal sinus measured by TRUPC, aTRUPC, and blood gas oximetry were obtained. The Y_v

SUBMITTER: Jiang D 

PROVIDER: S-EPMC8184598 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature